NFL · Week 4 · Sunday, October 4, 2026
Denver Broncos vs San Francisco 49ers — Odds, Spread & Total
Kickoff 16:25 ET
EdgeBets Model Projection
Projected margin
San Francisco 49ers by 4.2
Market spread at publication
-2.5
Our projected margin is 1.7 points wider than the market's spread.
Our ratings lean San Francisco 49ers.
Our model's projection, shown for informational purposes — not betting advice, and not a claim to beat the market.
The Market on This Game
as of Oct 4, 12:00 PM ETBest moneyline price: Denver Broncos +136 at DraftKings · San Francisco 49ers -142 at FanDuel
Every sportsbook: spread, total and moneyline
| Sportsbook | San Francisco 49ers | Denver Broncos | Spread | Total |
|---|---|---|---|---|
| bet365🌎 | -159 | +135 | -2.5(-124) | 48.5(o-106 / u-114) |
| BetMGM🇺🇸 | -152 | +128 | -2.5(-122) | 47.5(o-114 / u-106) |
| BetRivers🇺🇸 | -165 | +135 | -3(-105) | 48(o-110 / u-108) |
| Caesars🇺🇸 | -157 | +130 | -3(-108) | 47.5(o-112 / u-108) |
| DraftKings🇺🇸 | -162 | +136Best | -3(-105) | 48.5(o-105 / u-115) |
| FanDuel🇺🇸 | -142Best | +120 | -2.5(-110) | 46.5(o-110 / u-110) |
6 sportsbooks shown. Prices are the latest captured snapshot for each book, not a live feed.
Denver Broncos vs San Francisco 49ers: the numbers on this game
Denver Broncos play San Francisco 49ers on Sunday, October 4, 2026, Week 4 of the 2026 NFL season, kicking off at 16:25 ET.
Across 6 books the point spread runs -3 to -2.5, the game total 46.5 to 48.5, and the San Francisco 49ers moneyline -165 to -142. Worth a minute of comparing before you take a price.
Odds are collected from public sportsbook feeds on a schedule and carry the timestamp they were captured — lines move, so confirm the number at the sportsbook before betting. EdgeBets does not take bets and does not claim to beat the closing line. 19+. Please bet responsibly.
Other NFL games on Sunday, October 4, 2026
- Indianapolis Colts vs Washington Commanders · 09:30 ET
- Tennessee Titans vs Baltimore Ravens · 13:00 ET
- New England Patriots vs Buffalo Bills · 13:00 ET
- New York Jets vs Chicago Bears · 13:00 ET
- Jacksonville Jaguars vs Cincinnati Bengals · 13:00 ET
- Dallas Cowboys vs Houston Texans · 13:00 ET
- Arizona Cardinals vs New York Giants · 13:00 ET
- Los Angeles Rams vs Philadelphia Eagles · 13:00 ET
- Green Bay Packers vs Tampa Bay Buccaneers · 13:00 ET
- Miami Dolphins vs Minnesota Vikings · 16:05 ET
- Kansas City Chiefs vs Las Vegas Raiders · 16:25 ET
- Los Angeles Chargers vs Seattle Seahawks · 16:25 ET