MLB · Wednesday, September 16, 2026
San Francisco Giants vs St. Louis Cardinals — Prediction, Projected Score & Odds
San Francisco Giants schedule & results·St. Louis Cardinals schedule & results
First pitch 13:15 (local)
EdgeBets Model Projection
San Francisco Giants
4.4
Projected Total
9.4
St. Louis Cardinals
5.0
Our model's simulation, shown for informational purposes — not betting advice, and not a claim to beat the market.
Moneyline Odds by Sportsbook
as of Sep 16, 9:00 AM ET| Book | San Francisco Giants | St. Louis Cardinals |
|---|---|---|
| betmgm | +136 | -162 |
| betrivers | +135 | -165 |
| caesars | +133 | -157 |
| draftkings | +136 | -164 |
| fanduel | +130 | -156 |
| pinnacle | +142 | -158 |
Best available price: San Francisco Giants +142 at Pinnacle. St. Louis Cardinals -156 at FanDuel.
San Francisco Giants vs St. Louis Cardinals: the matchup & where to bet it
EdgeBets' model projects San Francisco Giants vs St. Louis Cardinals at about 4.4–5.0, a total near 9.4 runs. The San Francisco Giants moneyline ranges from +130 to +142 across 6 books — prices are tight across the market here. Right now the best prices are +142 (pinnacle) on San Francisco Giants and -156 (fanduel) on St. Louis Cardinals.
EdgeBets does not claim to beat the closing line or guarantee outcomes. Projections are informational. 19+. Please bet responsibly.